Book Hotels in South San Diego, CA

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Top South San Diego hotels

Pendry San Diego

Pendry San Diego

5 out of 5
550 J Street San Diego CA
Fully refundableReserve now, pay when you stay
$370 nightly
The price is $429 total per night from Jan 13 to Jan 14
$429 total
Jan 13 - Jan 14
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
The room was clean, tasteful, and quiet. The staff was very friendly and helpful. We had a wonderful time in Pendry.

Reviewed on Jan 1, 2026

Opens in a new windowPendry San Diego
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $154 total per night from Jan 25 to Jan 26
$154 total
Jan 25 - Jan 26
Total with taxes and fees
A marina, a gym, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas and free ...
Beautiful views from room 248! Great service throughout our stay from all the departments! Quiet, serenely quiet which we really enjoyed. Everything was clean, spacious, kept up and easy to navigate.

Reviewed on Jan 6, 2026

Opens in a new windowBay Club Hotel & Marina
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

4 out of 5
1646 Front St San Diego CA
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $161 total per night from Jan 19 to Jan 20
$161 total
Jan 19 - Jan 20
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and free internet ...
I enjoyed the stay. Staff was pleasant just upset the ice machine didn’t work and could of used more towels

Reviewed on Jan 5, 2026

Opens in a new windowCourtyard by Marriott San Diego Downtown Little Italy
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $128 total per night from Jan 22 to Jan 23
$128 total
Jan 22 - Jan 23
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Linen service for the room, staff, and fruit-infused water.

Reviewed on Jan 5, 2026

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$166 nightly
The price is $191 total per night from Jan 11 to Jan 12
$191 total
Jan 11 - Jan 12
Total with taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. If you want to take your pet along, this pet-friendly property offers everything ...
We did not eat breakfast on site

Reviewed on Jan 5, 2026

Opens in a new windowThe Dana on Mission Bay
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$237 nightly
The price is $274 total per night from Jan 14 to Jan 15
$274 total
Jan 14 - Jan 15
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
great

Reviewed on Jan 6, 2026

Opens in a new windowHard Rock Hotel San Diego
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$207 nightly
The price is $238 total per night from Jan 11 to Jan 12
$238 total
Jan 11 - Jan 12
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
Spotless

Reviewed on Jan 6, 2026

Opens in a new windowSheraton San Diego Resort
DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley

4 out of 5
7450 Hazard Center Dr San Diego CA
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $138 total per night from Jan 25 to Jan 26
$138 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 20 conference rooms, free WiFi in public areas, ...
The staff was kind and courteous , the rooms were clean, well and supplied with necessities. We received free cookies upon entry, the gym, indoor pool and jacuzzi were amazing. The only surprise that was quite significant and is not mentioned in the Expedia or hotel site description is that doubletree ...

Reviewed on Jan 5, 2026

Opens in a new windowDoubleTree by Hilton Hotel San Diego - Mission Valley
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S San Diego CA
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $141 total per night from Jan 18 to Jan 19
$141 total
Jan 18 - Jan 19
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Can room

Reviewed on Jan 9, 2026

Opens in a new windowHilton San Diego Mission Valley
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap South San Diego hotels

The Rambler

The Rambler

225 Bay Blvd Chula Vista CA
$98 nightly
The price is $114 total per night from Jan 12 to Jan 13
$114 total
Jan 12 - Jan 13
Total with taxes and fees
9/10 Wonderful! (2,016 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent South San Diego hotel reviews by fellow wanderers

Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Can room"
A verified traveler stayed at Hilton San Diego Mission Valley
Hilton San Diego Mission Valley

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